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Oral Contraceptives and Cancer Risk | Women's Health First

Oral Contraceptives and Cancer Risk

Oral contraceptives (OCs) first became available to American women in the early 1960s. The convenience, effectiveness, and reversibility of action of birth control pills (popularly known as ?the pill?) have made them the most popular form of birth control in the United States. However, concerns have been raised about the role that the hormones in OCs might play in a number of cancers, and how hormone-based OCs contribute to their development. Sufficient time has elapsed since the introduction of OCs to allow investigators to study large numbers of women who took birth control pills for many years.

This fact sheet addresses only what is known about OC use and the risk of developing cancer. It does not deal with other serious side effects of OC use, such as the increased risk of cardiovascular disease for certain groups of women. Recently, alternative methods of delivering hormones for contraception have been developed, including a topical patch, vaginal ring, and intrauterine delivery system, but these products are too new to have been tested in clinical trials (research studies) for long-term safety and other effects (1). They also are not covered in this fact sheet.

What types of oral contraceptives are available in the United States and Why do researchers believe that oral contraceptives may influence cancer risk?

Currently, two types of OCs are available in the United States. The most commonly prescribed OC contains two man-made versions of natural female hormones (estrogen and progesterone) that are similar to the hormones the ovaries normally produce. This type of pill is often called a ?and progesterone.? The second type of OC available in the United States is called the minipill. It contains only a type of progesterone. Estrogen stimulates the growth and development of the uterus at puberty, causes the endometrium (the inner lining of the uterus) to thicken during the first half of the menstrual cycle, and influences breast tissue throughout life, but particularly from puberty to menopause.Progesterone, which is produced during the last half of the menstrual cycle, prepares the endometrium to receive the egg. If the egg is fertilized, progesterone secretion continues, preventing release of additional eggs from the ovaries. For this reason, progesterone is called the ?pregnancy-supporting? hormone, and scientists believe that it has valuable contraceptive effects. The man-made progesterone used in OCs is called progestogen or progestin.

Because medical research suggests that some cancers depend on naturally occurring sex hormones for their development and growth, scientists have been investigating a possible link between OC use and cancer risk. Researchers have focused a great deal of attention on OC users over the past 40 years. This scrutiny has produced a wealth of data on OC use and the development of certain cancers, although results of these studies have not always been consistent. The risk of endometrial and ovarian cancers is reduced with the use of OCs, while the risk of breast and cervical cancers is increased (1). A summary of research results for each type of cancer is given in Questions 2?5.

How do oral contraceptives affect breast cancer risk?

A woman?s risk of developing breast cancer depends on several factors, some of which are related to her natural hormones. Hormonal factors that increase the risk of breast cancer include conditions that may allow high levels of hormones to persist for long periods of time, such as beginning menstruation at an early age (before age 12), experiencing menopause at a late age (after age 55), having a first child after age 30, and not having children at all.A 1996 analysis of worldwide epidemiologic data conducted by the Collaborative Group on Hormonal Factors in Breast Cancer found that women who were current or recent users of birth control pills had a slightly elevated risk of developing breast cancer. The risk was highest for women who started using OCs as teenagers. However, 10 or more years after women stopped using OCs, their risk of developing breast cancer returned to the same level as if they had never used birth control pills, regardless of family history of breast cancer, reproductive history, geographic area of residence, ethnic background, differences in study design, dose and type of hormone, or duration of use. In addition, breast cancers diagnosed in women after 10 or more years of not using OCs were less advanced than breast cancers diagnosed in women who had never used OCs. To conduct this analysis, the researchers examined the results of 54 studies. The analysis involved 53,297 women with breast cancer and 100,239 women without breast cancer. More than 200 researchers participated in this combined analysis of their original studies, which represented about 90 percent of the epidemiological studies throughout the world that had investigated the possible relationship between OCs and breast cancer (2).The findings of the Women?s Contraceptive and Reproductive Experiences (Women?s CARE) study were in contrast to those described above. The Women?s CARE study examined the use of OCs as a risk factor for breast cancer in women ages 35 to 64. Researchers interviewed 4,575 women who were diagnosed with breast cancer between 1994 and 1998, and 4,682 women who did not have breast cancer. Investigators collected detailed information about the participants? use of OCs, reproductive history, health, and family history. The results, which were published in 2002, indicated that current or former use of OCs did not significantly increase the risk of breast cancer. The findings were similar for white and black women. Factors such as longer periods of use, higher doses of estrogen, initiation of OC use before age 20, and OC use by women with a family history of breast cancer were not associated with an increased risk of the disease (3).

In a National Cancer Institute (NCI)-sponsored study published in 2003, researchers examined risk factors for breast cancer among women ages 20 to 34 compared with women ages 35 to 54. Women diagnosed with breast cancer were asked whether they had used OCs for more than 6 months before diagnosis and, if so, whether the most recent use had been within 5 years, 5 to 10 years, or more than 10 years. The results indicated that the risk was highest for women who used OCs within 5 years prior to diagnosis, particularly in the younger group (4).

How do oral contraceptives affect ovarian and endometrial cancer risk?

Studies have consistently shown that using OCs reduces the risk of ovarian cancer. In a 1992 analysis of 20 studies of OC use and ovarian cancer, researchers from Harvard Medical School found that the risk of ovarian cancer decreased with increasing duration of OC use. Results showed a 10 to 12 percent decrease in risk after 1 year of use, and approximately a 50 percent decrease after 5 years of use (5).

Researchers have studied how the amount or type of hormones in OCs affects ovarian cancer risk reduction. One of the studies used in the Harvard analysis, the Cancer and Steroid Hormone Study (CASH), found that the reduction in ovarian cancer risk was the same regardless of the type or amount of estrogen or progestin in the pill (6). A more recent analysis of data from the CASH study, however, indicated that OC formulations with high levels of progestin reduced ovarian cancer risk more than preparations with low progestin levels (7). In another recent study, the Steroid Hormones and Reproductions (SHARE) study, researchers investigated new, lower-dose progestins that have varying androgenic properties (testosterone-like effects). They found no difference in ovarian cancer risk between androgenic and nonandrogenic pills (8).

OC use in women at increased risk of ovarian cancer due to BRCA1 and BRCA2 genetic mutations has been studied. One study showed a reduction in risk, but a more recent study showed no effect (9, 10).

The use of OCs has been shown to significantly reduce the risk of endometrial cancer. This protective effect increases with the length of time OCs are used, and continues for many years after a woman stops using OCs (11).

How do oral contraceptives affect cervical cancer risk?

Evidence shows that long-term use of OCs (5 or more years) may be associated with an increased risk of cancer of the cervix (the narrow, lower portion of the uterus) (12). Although OC use may increase the risk of cervical cancer, human papillomavirus (HPV) is recognized as the major cause of this disease. Approximately 14 types of HPV have been identified as having the potential to cause cancer, and HPVs have been found in 99 percent of cervical cancer biopsy specimens worldwide (12). More information about HPV and cancer is available in Human Papillomaviruses and Cancer: Questions and Answers at http://www.cancer.gov/cancertopics/factsheet/risk/HPVon the Internet.A 2003 analysis by the International Agency for Research on Cancer (IARC) found an increased risk of cervical cancer with longer use of OCs. Researchers analyzed data from 28 studies that included 12,531 women with cervical cancer. The data suggested that the risk of cervical cancer may decrease after OC use stops (13). In another IARC report, data from eight studies were combined to assess the effect of OC use on cervical cancer risk in HPV-positive women. Researchers found a fourfold increase in risk among women who had used OCs for longer than 5 years. Risk was also increased among women who began using OCs before age 20 and women who had used OCs within the past 5 years (14). The IARC is planning a study to reanalyze all data related to OC use and cervical cancer risk (12).

How do oral contraceptives affect liver cancer risk?

Several studies have found that OCs increase the risk of liver cancer in populations usually considered low risk, such as white women in the United States and Europe who do not have liver disease. In these studies, women who used OCs for longer periods of time were found to be at increased risk for liver cancer. However, OCs did not increase the risk of liver cancer in Asian and African women, who are considered high risk for this disease. Researchers believe this is because other risk factors, such as hepatitis infection, outweigh the effect of OCs (15).

What screening tests are available for the cancers described?

Studies have found that regular breast cancer screening with mammograms reduces the number of deaths from breast cancer for women ages 40 to 69.? Women who are at increased risk for breast cancer should seek medical advice about when to begin having mammograms and how often to be screened. A high-quality mammogram, with a clinical breast exam (an exam done by a professional health care provider), is the most effective way to detect breast cancer early.Abnormal changes in the cervix can often be detected by a Pap test and treated before cancer develops. Women who have begun to have sexual intercourse or are age 21 should check with their doctor about having a Pap test. Researchers are working on developing screening tests for ovarian and endometrial cancer.Women who are concerned about their risk for cancer are encouraged to talk with their health care provider. More information is also available from the Cancer Information Service (see below).

Selected References

1. Burkman R, Schlesselman JJ, Zieman M. Safety concerns and health benefits associated with oral contraception. American Journal of Obstetrics and Gynecology 2004; 190(4 Suppl):S5?22.
2. Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53,297 women with breast cancer and 100,239 women without breast cancer from 54 epidemiological studies. Lancet 1996; 347:1713?1727.
3. Marchbanks PA, McDonald JA, Wilson HG, et al. Oral contraceptives and the risk of breast cancer. New England Journal of Medicine 2002; 346(26):2025?2032.
4. Althuis MD, Brogan DD, Coates RJ, et al. Breast cancers among very young premenopausal women (United States). Cancer Causes and Control 2003; 14(2):151?160.
5. Hankinson SE, Colditz GA, Hunter DJ, et al. A quantitative assessment of oral contraceptive use and risk of ovarian cancer. Obstetrics and Gynecology 1992; 80(4):708?714.
6. Centers for Disease Control and Prevention and the National Institute of Child Health and Human Development. The reduction in risk of ovarian cancer associated with oral-contraceptive use. The Cancer and Steroid Hormone Study of the Centers for Disease Control and the National Institute of Child Health and Human Development. New England Journal of Medicine 1987; 316(11):650?655.
7. Schildkraut JM, Calingaert B, Marchbanks PA, Moorman PG, Rodriguez GC. Impact of progestin and estrogen potency in oral contraceptives on ovarian cancer risk. Journal of the National Cancer Institute 2002; 94(1):32?38.
8. Greer JB, Modugno F, Allen GO, Ness RB. Androgenic progestins in oral contraceptives and the risk of epithelial ovarian cancer. Obstetrics and Gynecology 2005; 105(4):731?740.
9. Narod SA, Risch H, Moslehi R, et al. Oral contraceptives and the risk of hereditary ovarian cancer. Hereditary Ovarian Cancer Clinical Study Group. New England Journal of Medicine 1998; 339(7):424?428.
10. Modan B, Hartge P, Hirsh-Yechezkel G, et al. Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation. New England Journal of Medicine 2001; 345(4):235?240.
11. Emons G, Fleckenstein G, Hinney B, Huschmand A, Heyl W. Hormonal interactions in endometrial cancer. Endocrine-Related Cancer 2000; 7(4):227?242.
12. Franceschi S. The IARC commitment to cancer prevention: The example of papillomavirus and cervical cancer. Recent Results in Cancer Research 2005; 166:277?297.
13. Smith JS, Green J, Berrington de GA, et al. Cervical cancer and use of hormonal contraceptives: A systematic review. Lancet 2003; 361(9364):1159?1167.
14. Moreno V, Bosch FX, Munoz N, et al. Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: The IARC multicentric case-control study. Lancet 2002; 359(9312):1085?1092.
15. Yu MC, Yuan JM. Environmental factors and risk for hepatocellular carcinoma. Gastroenterology 2004; 127(5 Suppl 1):S72?S78.

Source: National Cancer Institute

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Weather reduces Singapore Classic to 54 holes

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Surprised And Inspired 10 Specialty Summer Camps For Kids and ...

You?ll be surprised and inspired by these unique ideas!

With more than 6 million kids in the U.S attending camp every summer, camp remains one of America?s favorite pastimes. Yet there is a new camp experience that has dramatically increased in popularity over the last decade ? and that is the ?specialty? camp. Never before have kids and teens had so many one-of-a-kind camp options to choose from.

While traditional camps offer programs that encourage kids to try a variety of activities, a specialty camp focuses on one topic ? or a few related topics. There are now thousands of unique (and sometimes unusual) day and overnight summer camps inspiring children and teens to learn more about what they love.

After considerable research, we?ve gathered a list of some of America?s most unique and rewarding specialty summer camps. Take a look:

ACTING FOR FILM CAMP

Young Actors Camp Location: Hollywood, CaliforniaAges: 7-19

For kids and teens who dream of acting for the silver screen, this camp is the ultimate learning experience. At Young Actors Camp, campers are taught the tools-of-the-trade for succeeding in Hollywood?s film and television acting industries ? and the word on the street is, they have a great time doing so.

This overnight summer camp offers four programs to choose from that include pre-professional activities such as taking headshots, writing a resume, building auditioning skills and improving film-acting techniques.

And what really excites kids is their chance to be in a real Hollywood movie. All YAC campers visit working movie sets and meet real Hollywood movie stars (who come by camp to offer advice and technique tips). This is a true chance of a lifetime for young actors dying to get a glimpse into the world they dream of succeeding in ? and after attending Young Actors Camp, kids have a much better chance of doing so.

Young Actors Camp is the only summer camp experience that can lead to a young actor moving to Los Angeles for real work opportunities; and YAC will guide actors and families through the transitional period of this complicated, yet rewarding, process.

SURF CAMP

WB Surf Camp Location: Wrightsville Beach, North Carolina ?Ages: 6-18

This seriously radical camp is a dream-come-true for kids and teens (and adults!) who want to learn how to surf. WB Surf Camp offers a wide variety of summer camp options. From day and overnight camps to advanced private lessons and international surf tours, WB Surf Camp does it all.

WB teaches kids how to predict, select and ride waves, but they also educate surfing beginners about ocean safety (rip current identification, surf and sun advisories and first-aid), coastal environments, marine life and ocean dynamics.

At this full immersion camp, kids gain knowledge, confidence and surfing ability through progressive and professional instruction ? and they have an awesome time doing it!

CIRCUS CAMP

Camp Winnarainbow Location: Mendocino, CaliforniaAges: 7-14

Learning about the BIG TOP is BIG FUN! This colorful and positive camp embraces the joy of creativity and personal achievement. For 30 years, Winnarainbow camp leaders have been teaching kids about circus performing arts techniques, such as timing, balance, humor, acting, juggling, dancing, gymnastics, the tightrope, the trapeze, clowning, falling, magic and much more!

Along with the great fun of clowning around, Camp Winnarainbow is also dedicated to providing a beautiful training ground in Northern California that supports a strong communion with nature. One of the camp?s main goals is to show future kids how to embrace and contribute to a harmonious and sustainable world. The creative spirit is nurtured in an atmosphere of approval and mutual encouragement. This truly unique camp experience leaves kids with a powerful sense of the creative community.

COOKING CAMP

Chef Kelly Q. Dietrich?s Kids Culinary Summer of VermontLocation: Highgate Center, VermontAges: 10+

For kids who are always asking to help in the kitchen and have a natural love for cooking and baking, there isn?t a more suitable camp than Kids Culinary Summer Camp. Offering two programs ? The Saut? Kitchen and The Baking and Pastry Arts ? this taster?s delight introduces kids to the life of a chef.

A wide berth of culinary skills are taught during the one or two week summer camp sessions, including menu planning, bread and pastry baking, beef and poultry cooking, vegetable cookery, seafood, garnishes, cake decorating, soups and sauces, ethnic cooking, knife and chopping skills, utensil skills, kitchen hygiene and healthy eating habits.

And it?s not all just about the kitchen! The curriculum also includes valuable lessons about nutrition and organic food sources; aquaponics (the integrated growing of tilapia fish and micro-greens and herbs in our greenhouse); organic square foot and container gardening; composting beekeeping; and olive oil herbing and bottling.

This unique camp experience provides kids and teens with valuable skills to use with their families throughout the year, in addition to learning how to pursue a career in the culinary arts. Wouldn?t it be amazing for you son or daughter to skillfully prepare delicious meals for the family on a daily basis?

ARCHEOLOGICAL CAMP

Canyon Crow Summer Camp Location: Cortez, ColoradoAges: 12+

Are your kids constantly out in the yard looking for old arrowheads or digging for buried pottery and other hidden treasures? Well, now there?s a perfect summer camp for these little archeologists to-be.

At Canyon Crow?s overnight summer camp, kids and teens are invited to study the fascinating past of Pueblo Indians who lived in the American Southwest?s Four Corners area. During their weeklong stay, campers join professional archeologists at a real excavation site to learn the proper procedure of sorting and identifying important artifacts.

Kids also have great fun playing traditional Native American games like spear throwing with an atlati and learning ancient practices like building a fire without matches. This interesting camp experience brings kids closer to the heritage of our country and the people who inhabited the region 700 to 2500 years ago.

SPY CAMP

Camp Lohikan Location: Lake Como, PennsylvaniaAges: 7+

Camp Lohikan has taken the game of hide-and-seek to a whole new level. Here campers learn the secrets behind covert operations as they train for exciting missions. Spy camp teaches teamwork, critical thinking, practical skills and physical discipline.

Lohikan?s mini-agents train on 4-wheelers, jet skis and rope courses for quick getaways. (But don?t worry, ?quick getaways? in reality means learning safe, evasive driving techniques.)

Kids are also taught combat tactics, martial arts, how to conduct surveillance, code breaking, survival training, interrogation techniques undercover maneuvers and even paintball! (Paintball is limited to 5th grade and up.)

At Camp Lohikan the mission truly IS possible. And what?s the final camp mission? Finding the mole! The kids? final exam is to participate in a role-playing adventure that is, as they say, ?high octane FUN.? This specialty camp experience is an exciting opportunity to understand exactly what it means to be a spy.

GARDENING CAMP

Children?s Peace Summer Camp Location: Boulder, ColoradoAges: 4-10

Children?s Peace takes kids back to the roots of a simpler time. Spending warm summer days learning about the beauty of the natural world is a wholesome experience that any child will benefit from and enjoy.

This non-profit day camp teaches campers organic gardening practices and environmental stewardship, in addition to the importance of biodiversity and sustainability.

All hands-on activities encourage peace, respect, friendship and the beauty of connecting with the earth. And Children?s Peace is a lot of fun! Beyond gardening, camp activities include scavenger hunts, writing poetry, dancing, making natural dyes from vegetables and candles from bee hive wax and creating a rich variety of art to be appreciated at community coffee shops.

Fashion CampSewnow! Fashion Studio Location: Lafayette, CaliforniaAges: 2nd grade and up

If much to your dismay, your little Diane von Furstenberg is cutting up their clothes only to sew them back together again, it might be time to send them to Sewnow! Fashion Studio. At this overnight summer camp, open to boys and girls, kids are allowed to let their creative colors fly.

Known for being a fun, energetic and friendly atmosphere, Sewnow! is a great experience for those starting from scratch, as well as kids with ample experience. Beginners will learn things like basic sewing, cutting and assembly methods, while advanced campers will learn about computerized drafting systems and machine embroidery.

So if your son or daughter is glued to the TV every time Project Runway comes on, this could be his or her own chance of a lifetime.

ASTRONOMY CAMP

Astronomy Camp Location: Tucson, ArizonaAges: 12-17

This camp is truly out of this world. At Arizona?s longest running science camp, kids are invited to explore the universe by operating research-class telescopes. For the young scientist, engineer, physicist, astronomer and astronaut this experience could be the perfect opportunity to accelerate their hobby and motivate them to explore further.

Astronomy Camp is a full immersion overnight camp where young night owls keep nighttime hours, interact with leading scientists, interpret their own observations and have a great deal of fun hanging out with likeminded kids.

During daylight, campers get to participate in

Related posts:

1. From Beach To Specialty Camps Abound!
2. Americas Coolest Summer Camps
3. Summer Day Camp or Overnight Camp
4. Tips And Tricks Summer Vacation Homes Efficient Money Spending
5. P90X Boot Camps Littleton

Pages: 1 2

Tags: Camps, Kids, Specialty, Summer, Teens

This entry was posted on Sunday, April 8th, 2012 at 1:17 pm and is filed under Camping. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.

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Internet Business Opportunities | Income Online Open Day Is About ...

April 7, 2012 ? 12:02 pm

?Income Online open day? is about to take place at Empower network Ltd. The news has attracted positive comments from people who visit the site.

Houston, TX. (PRWEB) April 05, 2012

Pat Coringer, One of the Directors on the site said that ?this day will be filled with Internet Business opportunities to make a lot of money for those people who want to commit themselves to the process of starting up something online. We have not decided on a time or location for the open day yet but we do know that we will have a number of experts in place on the day that have made a lot of money online who are willing to share opportunities with other people who want to do the same thing. We would encourage anyone who likes the idea of having a home business to come down to the open day and talk to one of our people about it?.

The news of the ? Income Online open day? has spread to a number of sites that are in the same niche as Empower network Ltd. and many of these sites have attracted comments from people about the open day. Most of the commentators have been very positive so far about what they think of the new open day and many of them are looking forward to attending the day itself.

As well as coming up with this new open day the team at Empower network Ltd. have also come up with some free information this week on how to make money online. This information is available for free right now at .

Jose C. Boydempowernetwork.com978-874-6879 Email Information

Tags: internet business opportunities

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HBT: Chipper feels good after facing live pitching

Chipper Jones has already resumed facing live pitching, less than two weeks removed from arthroscopic surgery to repair a torn meniscus in his left knee.

According to Mark Bowman of MLB.com, Jones felt ?real good? taking swings against teammate Randall Delgado in a simulated game this afternoon at Citi Field. While the 39-year-old believes he ?will be ready physically? to come off the disabled list when he?s first eligible on Tuesday, he also acknowledged that he might need a few additional days to work on his timing.

With that in mind, the Braves would prefer that Jones play in at least one minor league rehab game. Bowman suggests that could happen Thursday with Class A Rome, which could set up his potential return for the Braves? home opener next Friday against the Brewers.

Martin Prado and Juan Francisco will fill in at third base until Jones is ready to return. Francisco, who was recently acquired from the Reds, is slated to start at the hot corner Saturday and Sunday against the Mets.

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The business telephone system Westminster London | Smart Info ...

06.04.2012 Business, Phone Systems

Company Managers can learn some valuable lessons from Football Managers. The very best managers have the knack of communicating their message to their players in a way to motivate them to play their best. The manager must get across his point to his team in a firm and authoritive way and make decisions in a way it helps the team at critical times to achieve the best results. There must be mutual respect. There must be acknowledgment for the achievement of good results and this praise must be include all of the team.
This what we pointed out to our new customer in Westminster when we were advising him on the business telephone system. The communications in all business environments is a key aspect of the success of any business. It is vital that the business telephone system has all the functionality included that will benefit the business most. By analysing what the business does and what will improve the customer and internal communications this information is used to determine what to supply.
The customer said ?We are so pleased you did the in-depth examination of how we use the business telephone and how we could improve it. We are now enjoying the new system and its benefits?

If you require a free quote for any our products contact number is 020 7377 9243.

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